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Miller MJ, Akter D, Mahmud J, Chan GC. Human cytomegalovirus modulates mTORC1 to redirect mRNA translation within quiescently infected monocytes. J Virol. 2024 Feb 20;98(2):e0188823. doi: 10.1128/jvi.01888-23. Epub 2024 Jan 30. PMID: 38289104; PMCID: PMC10878035.

Cheung J, Remiszewski S, Chiang LW, Ahmad E, Pal M, Rahman SA, Nikolovska-Coleska Z, Chan GC. Inhibition of SIRT2 promotes death of human cytomegalovirus-infected peripheral blood monocytes via apoptosis and necroptosis. Antiviral Res. 2023 Aug 9;217:105698. doi: 10.1016/j.antiviral.2023.105698. Epub ahead of print. PMID: 37562606.


Smith NA, Chan GC, O'Connor CM. Modulation of host cell signaling during cytomegalovirus latency and reactivation. Virol J. 2021 Oct 18;18(1):207. doi: 10.1186/s12985-021-01674-1. PMID: 34663377; PMCID: PMC8524946.

Mahmud J, Chan GC. Analysis of Cytomegalovirus Glycoprotein and Cellular Receptor Interactions. Methods Mol Biol. 2021;2244:199-211. doi: 10.1007/978-1-0716-1111-1_10. PMID: 33555588.


Lloyd MG, Smith NA, Tighe M, Travis KL, Liu D, Upadhyaya PK, Kinchington PR, Chan GC, Moffat JF. A Novel Human Skin Tissue Model To Study Varicella-Zoster Virus and Human Cytomegalovirus. J Virol. 2020 Oct 27;94(22):e01082-20. doi: 10.1128/JVI.01082-20. PMID: 32878893; PMCID: PMC7592229.

Altman AM, Miller MJ, Mahmud J, Smith NA, Chan GC. 2020. Human cytomegalovirus-induced autophagy prevents necroptosis of infected monocytes. J Virol 94:e01022-20. .01022-20.

Guo D, Shi C, Wang L, Ji X, Zhang S, Luo J. A Rationally Designed Micellar Nanocarrier for the Delivery of Hydrophilic Methotrexate in Psoriasis Treatment. ACS Appl Bio Mater. 2020 Aug 17;3(8):4832-4846. doi: 10.1021/acsabm.0c00342. Epub 2020 Jul 22. PubMed PMID: 34136761; PubMed Central PMCID: PMC8204631.

Fulkerson HL, Chesnokova LS, Kim JH, Mahmud J, Frazier LE, Chan GC, Yurochko AD. HCMV-induced signaling through gB-EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19507-19516. doi: 10.1073/pnas.2003549117. Epub 2020 Jul 28. PubMed PMID: 32723814; PubMed Central PMCID: PMC7431034.

Mahmud J, Miller MJ, Altman AM, Chan GC. 2020. Human cytomegalovirus glycoprotein-initiated signaling mediates the aberrant activation of Akt. J Virol 94:e00167-20.

Cojohari O, Mahmud J, Altman AM, Peppenelli MA, Miller MJ, Chan GC. Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network. Viruses. 2020 Jun 17;12(6):652. doi: 10.3390/v12060652. PMID: 32560319; PMCID: PMC7354488.


E X, Meraner P, Lu P, Perreira JM, Aker AM, McDougall WM, Zhuge R, Chan GC, Gerstein RM, Caposio P, Yurochko AD, Brass AL, Kowalik TF. OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7043-7052. doi: 10.1073/pnas.1814850116. Epub 2019 Mar 20. PubMed PMID: 30894498; PubMed Central PMCID: PMC6452726.

Altman AM, Mahmud J, Nikolovska-Coleska Z, Chan G. HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention? Antiviral Res. 2019 Mar;163:82-90. doi: 10.1016/j.antiviral.2019.01.009. Epub 2019 Jan 19. PMID: 30668978; PMCID: PMC6391997.


Peppenelli MA, Miller MJ, Altman AM, Cojohari O, Chan GC. Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes. Antiviral Res. 2018 Oct;158:13-24. doi: 10.1016/j.antiviral.2018.07.015. Epub 2018 Jul 25. PMID: 30055197; PMCID: PMC7899256.


Collins-McMillen D, Stevenson EV, Kim JH, Lee BJ, Cieply SJ, Nogalski MT, Chan GC, Frost RW 3rd, Spohn CR, Yurochko AD. Human Cytomegalovirus Utilizes a Nontraditional Signal Transducer and Activator of Transcription 1 Activation Cascade via Signaling through Epidermal Growth Factor Receptor and Integrins To Efficiently Promote the Motility, Differentiation, and Polarization of Infected Monocytes. J Virol. 2017 Dec 15;91(24). doi: 10.1128/JVI.00622-17. Print 2017 Dec 15. PubMed PMID: 29021395; PubMed Central PMCID: PMC5709601.


Burrer CM, Auburn H, Wang X, Luo J, Abulwerdi FA, Nikolovska-Coleska Z, Chan GC. Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes. Antiviral Res. 2017 Feb;138:40-46. doi: 10.1016/j.antiviral.2016.11.027. Epub 2016 Nov 30. PubMed PMID: 27914937; PubMed Central PMCID: PMC8246402.

Cojohari O, Peppenelli MA, Chan GC. 2016. Human Cytomegalovirus induces an atypical activation of Akt to stimulate the survival of short-lived monocytes. J Virol 90:6443–6452. doi:10.1128/JVI.00214-16.

Peppenelli MA, Arend KC, Cojohari O, Moorman NJ, Chan GC. Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes. J Virol. 2016 Jan 6;90(6):3138-47. doi: 10.1128/JVI.02879-15. PubMed PMID: 26739047; PubMed Central PMCID: PMC4810618.


Burrer CM, Foight GW, Keating AE, Chan GC. Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection. Virus Res. 2016 Jan 4;211:86-8. doi: 10.1016/j.virusres.2015.10.007. Epub 2015 Oct 9. PubMed PMID: 26456186; PubMed Central PMCID: PMC4792251.

Collins-McMillen D, Kim JH, Nogalski MT, Stevenson EV, Chan GC, Caskey JR, Cieply SJ, Yurochko AD. Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins. J Virol. 2015 Dec 16;90(5):2356-71. doi: 10.1128/JVI.01994-15. PubMed PMID: 26676786; PubMed Central PMCID: PMC4810730.

Cojohari O, Burrer CM, Peppenelli MA, Abulwerdi FA, Nikolovska-Coleska Z, Chan GC. 2015. BH3 profiling reveals selectivity by herpesviruses for specific Bcl-2 proteins to mediate survival of latently infected cells. J Virol 89:5739 –5746. doi:10.1128/JVI.00236-15.


Chan GC, Yurochko AD. Analysis of cytomegalovirus binding/entry-mediated events. Methods Mol Biol. 2014;1119:113-21. doi: 10.1007/978-1-62703-788-4_8. PubMed PMID: 24639221.


Nogalski MT, Chan GC, Stevenson EV, Collins-McMillen DK, Yurochko AD. The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes. PLoS Pathog. 2013;9(7):e1003463. doi: 10.1371/journal.ppat.1003463. Epub 2013 Jul 11. PubMed PMID: 23853586; PubMed Central PMCID: PMC3708883.


Nogalski MT, Chan GC, Stevenson EV, Collins-McMillen DK, Yurochko AD. A quantitative evaluation of cell migration by the phagokinetic track motility assay. J Vis Exp. 2012 Dec 4;(70):e4165. doi: 10.3791/4165. PubMed PMID: 23242175; PubMed Central PMCID: PMC3567159.

Chan G, Nogalski MT, Yurochko AD. Human cytomegalovirus stimulates monocyte-to-macrophage differentiation via the temporal regulation of caspase 3. J Virol. 2012 Oct;86(19):10714-23. doi: 10.1128/JVI.07129-11. Epub 2012 Jul 25. PubMed PMID: 22837201; PubMed Central PMCID: PMC3457328.

Chan G, Nogalski MT, Stevenson EV, Yurochko AD. Human cytomegalovirus induction of a unique signalsome during viral entry into monocytes mediates distinct functional changes: a strategy for viral dissemination. J Leukoc Biol. 2012 Oct;92(4):743-52. doi: 10.1189/jlb.0112040. Epub 2012 Jun 19. Review. PubMed PMID: 22715139; PubMed Central PMCID: PMC3441319.


Nogalski MT, Chan G, Stevenson EV, Gray S, Yurochko AD. Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry. J Virol. 2011 Feb;85(3):1360-9. doi: 10.1128/JVI.02090-10. Epub 2010 Nov 17. PubMed PMID: 21084488; PubMed Central PMCID: PMC3020497.


Chan G, Nogalski MT, Bentz GL, Smith MS, Parmater A, Yurochko AD. PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J Immunol. 2010 Mar 15;184(6):3213-22. doi: 10.4049/jimmunol.0903025. Epub 2010 Feb 19. PubMed PMID: 20173022; PubMed Central PMCID: PMC3743441.


Chan G, Nogalski MT, Yurochko AD. Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22369-74. doi: 10.1073/pnas.0908787106. Epub 2009 Dec 11. PubMed PMID: 20018733; PubMed Central PMCID: PMC2799688.

Chaudhuri S, Lowen B, Chan G, Davey A, Riddell M, Guilbert LJ. Human cytomegalovirus interacts with toll-like receptor 2 and CD14 on syncytiotrophoblasts to stimulate expression of TNFalpha mRNA and apoptosis. Placenta. 2009 Nov;30(11):994-1001. doi: 10.1016/j.placenta.2009.09.001. Epub 2009 Sep 30. PubMed PMID: 19796811.

Chan G, Bivins-Smith ER, Smith MS, Yurochko AD. NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes. Virus Res. 2009 Sep;144(1-2):329-33. doi: 10.1016/j.virusres.2009.04.026. Epub 2009 May 7. PubMed PMID: 19427341; PubMed Central PMCID: PMC2736317.


Chan G, Bivins-Smith ER, Smith MS, Smith PM, Yurochko AD. Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage. J Immunol. 2008 Jul 1;181(1):698-711. doi: 10.4049/jimmunol.181.1.698. PubMed PMID: 18566437; PubMed Central PMCID: PMC2614917.

Chan G, Bivins-Smith ER, Smith MS, Yurochko AD. Transcriptome analysis of NF-kappaB- and phosphatidylinositol 3-kinase-regulated genes in human cytomegalovirus-infected monocytes. J Virol. 2008 Jan;82(2):1040-6. doi: 10.1128/JVI.00864-07. Epub 2007 Nov 14. PubMed PMID: 18003728; PubMed Central PMCID: PMC2224586.


Smith MS, Bivins-Smith ER, Tilley AM, Bentz GL, Chan G, Minard J, Yurochko AD. Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence. J Virol. 2007 Jul;81(14):7683-94. doi: 10.1128/JVI.02839-06. Epub 2007 May 16. PubMed PMID: 17507481; PubMed Central PMCID: PMC1933358.


Bentz GL, Jarquin-Pardo M, Chan G, Smith MS, Sinzger C, Yurochko AD. Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV. J Virol. 2006 Dec;80(23):11539-55. doi: 10.1128/JVI.01016-06. Epub 2006 Sep 20. PubMed PMID: 16987970; PubMed Central PMCID: PMC1642592.


Johnstone ED, Chan G, Sibley CP, Davidge ST, Lowen B, Guilbert LJ. Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. J Lipid Res. 2005 Sep;46(9):1833-9. doi: 10.1194/jlr.M500095-JLR200. Epub 2005 Jul 1. PubMed PMID: 15995175.

Johnstone ED, Mackova M, Das S, Payne SG, Lowen B, Sibley CP, Chan G, Guilbert LJ. Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts. Placenta. 2005 Aug;26(7):548-55. doi: 10.1016/j.placenta.2004.08.012. PubMed PMID: 15993704.


Chan G, Stinski MF, Guilbert LJ. Human cytomegalovirus-induced upregulation of intercellular cell adhesion molecule-1 on villous syncytiotrophoblasts. Biol Reprod. 2004 Sep;71(3):797-803. doi: 10.1095/biolreprod.104.028118. Epub 2004 May 12. PubMed PMID: 15140794.


Chan G, Hemmings DG, Yurochko AD, Guilbert LJ. Human cytomegalovirus-caused damage to placental trophoblasts mediated by immediate-early gene-induced tumor necrosis factor-alpha. Am J Pathol. 2002 Oct;161(4):1371-81. doi: 10.1016/s0002-9440(10)64413-6. PubMed PMID: 12368210; PubMed Central PMCID: PMC1867293.

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